Table 2.
The role of lncRNAs in gene expression profiles of RA.
| lncRNAs Up (n) | lncRNAs Down(n) | mRNAs Up (n) | mRNAs Down(n) | Tissue (n) | Species | lncRNAs | Functions | Reference |
|---|---|---|---|---|---|---|---|---|
| 62 | 73 | 36 | 67 | RA-FLS (n=3) Normal-FLS (n=3) | Human | ENST00000483588, uc004afb.1, ENST00000438399,ENST00000452247 | Biomarker for RA diagnosis | (120) |
| 190 | 131 | 750 | 1025 | RA-synovial (n=5) Normal-synovial (n=5) | Human | RP11-83J16.1 | Proliferation, migration, invasion, inflammation | (121) |
| 349 | 806 | 1582 | 1295 | RA-synovial (n=3) Normal-synovial (n=3) | Human | lnc-AL928768.3, lnc-AC091493.1 | Biomarkers for RA risk and activity | (122) |
| 683 | 1,416 | 331 | 1,976 | RA-PBMC (n=3) Normal- PBMC (n=3) | Human | ENST00000456270 | Biomarker for RA diagnosis | (123) |
| 2410 | 2635 | 1403 | 1886 | RA-PBMC (n=1) Normal- PBMC (n=1) | Human | – | Biomarker for RA therapy | (124) |
| 231 | 110 | – | – | RA-PBMC (n=3) Normal- PBMC (n=3) | Human | MIR22HG, DSCR9, LINC01189, MAPKAPK5-AS1, ENST00000619282 | Biomarker for RA diagnosis Apoptosis, autophagy | (125) |
| 275 | 218 | 193 | 181 | RA-PBMC (n=2) Normal- PBMC (n=2) | Human | ENST00000569543 ENST00000420096 | Biomarker for RA diagnosis | (126) |
| 169 | 120 | 280 | 188 | RA-plasma (n=4) Normal- plasma (n=4) | Human | – | Biomarker for RA diagnosis and therapy | (127) |
FLS, Fibroblast−like synoviocytes; PBMC, peripheral blood mononuclear cell.