Table 4.

The role of circRNAs in gene expression profiles of RA.

circRNAs Up (n)	circRNAs Down(n)	Tissue (n)	Species	circRNAs	Functions	Reference
109	56	RA-PBMC (n=3) Normal-PBMC (n=3)	Human	circ_0001200,circ_0001566, circ_0003972, circ_0008360	Biomarker for RA diagnosis	(162)
109	56	RA-PBMC (n=3) Normal-PBMC (n=3)	Human	circ_0003353	Promote immunity, inflammation, synovial invasion	(163)
9	3	RA-PBMC (n=5) Normal-PBMC (n=5)	Human	circRNA_104871,circRNA_003524, circRNA_101873, circRNA_103047	Biomarkers for RA diagnosis	(164)
41	30	RA-PBMC (n=4) Normal-PBMC (n=3)	Human	circPTPN22	Biomarkers for RA diagnosis	(165)
10	0	RA- plasma (n=5) Normal-plasma (n=5)	Human	circ_0005008, circ_0005198	Disease activity Biomarkers for RA diagnosis	(166)

PBMC, Peripheral blood mononuclear cell.