Figure 2.

Interactions and functions of Th17 cells. A representation of the interactions of Th17 cells with other cell types: Through their production ligands for receptors on the surface of Th17 cells (IL-23R, CD161, CCR4 and CCR6), macrophages, monocytes and dendritic cells (CCL17, CCL22 and IL-23 production), T cells (LLT1, CLEC2D and PILAR) and epithelial cells (CCL20) participate in the activation of Th17 cells and their production of IL-17 cytokines. The IL-17 cytokines produced by Th17 cells activate epithelial cells, fibroblasts, and keratinocytes via their IL-17R surface receptor. Following this activation, these cells produce chemotactic factors (IL-6, CXCL2 and CXCL8) which participate in the recruitment of neutrophils. These cells also produce G-CSF and GM-CSF, which are involved in the differentiation of resident monocytes into resident macrophages and the increased production of macrophages and neutrophils in the bone marrow.