Table 2.
Group b | Incidence c | Mortality d | Disease forms e | ||
---|---|---|---|---|---|
Relapsing-remitting | Hyperacute | Secondary progressive | |||
Control | 10/12 | 2/10 | 8/10 | 1/10 | 1/10 |
Curdlan | 11/12 | 9/11* | 2/11 | 8/11 | 1/11 |
For EAE induction, SJL/J mice were sensitized subcutaneously with the myelin proteolipid protein (PLP)139-151 peptide emulsified in complete Freund’s adjuvant (CFA).
One day prior to PLP139-151 sensitization, mice from the control and curdlan treatment groups were injected intraperitoneally with phosphate-buffered saline (PBS) and curdlan, respectively.
Number of symptomatic mice/total number of mice sensitized with the PLP139-151/CFA emulsion.
Number of dead mice/total number of symptomatic mice. *P < 0.05, χ2 test, compared with controls.
Number of mice with each disease form/total number of symptomatic mice.