FIGURE 3.

MC-reconstruction in Sash mice declines anti-viral immune responses and rescues retroviral acquisition. (A) BMMCs (5 × 10⁶) were injected i.v. into Sash mice to reconstruct MCs. The splenic c-Kit⁺ FcεRI⁺ MCs were quantified. All mice were infected i.p. with MuLV/Friend (1 × 10⁹ copies) for 5 days, (B) the frequency and phenotype of splenic G-MDSCs were detected, (C) the IFN-γ expression in splenic NK and CD8⁺ T were measured, and (D) viral replication in spleen was quantified. One-way ANOVA was performed to analyze significance differences. Data are presented as mean ± SD. *p < 0.05, **p < 0.01 and ***p < 0.001 are considered significant differences.