FIGURE 5.

Mast cell stabilizer blocks cell activation and reduces acute retrovirus infection. (A) A schematic illustration of infection and treatment. C57BL/6 mice were infected i.p. with MuLV/Friend (1 × 10⁹ copies), and Ebastine (5 mg/kg) or Loratadine (10 mg/kg) was administered 1 day before infection and continued daily throughout infection. At 5 dpi, (B) the assay for MC degranulation, (C) viral loads in spleen were quantified, (D) the frequency and phenotype of splenic G-MDSCs were profiled, and (E) the IFN-γ expression in splenic NK, CD8⁺ T and CD4⁺ T cells were measured. One-way ANOVA was performed to analyze significance differences. Data are presented as mean ± SD. *p < 0.05, **p < 0.01 and ***p < 0.001 are considered significant differences.