. 2022 Feb 7;13:842846. doi: 10.3389/fendo.2022.842846

Table 2.

Sensitivity analyses of the causal associations of circulating α-Klotho levels with cardiovascular diseases.

Outcomes	Data sources	P_{Cochran’s Q}	P_intercept	P_{MR-PRESSO global test}
Coronary artery disease	CARDIoGRAMplusC4D	0.477	0.537	0.474
Coronary artery disease	FinnGen	0.077	0.630	0.116
Atrial fibrillation	Nielsen et al.	0.162	0.321	0.103
Atrial fibrillation	FinnGen	0.235	0.749	0.133
Heart failure	HERMES	0.667	0.443	0.586
Heart failure	FinnGen	0.820	0.362	0.781
Any stroke	MEGASTROKE	0.778	0.274	0.771
Any stroke	FinnGen	0.385	0.063	0.395
Ischemic stroke	MEGASTROKE	0.946	0.471	0.939
Ischemic stroke	FinnGen	0.042	0.006	0.052
Large artery stroke	MEGASTROKE	0.556	0.726	0.456
Small vessel stroke	MEGASTROKE	0.194	0.029	0.244
Cardioembolic stroke	MEGASTROKE	0.761	0.628	0.746

CARDIoGRAMplusC4D, Coronary ARtery DIsease Genome-wide Replication and Meta-analysis (CARDIoGRAM) plus The Coronary Artery Disease (C4D) Genetics; HERMES, Heart Failure Molecular Epidemiology for Therapeutic Targets.