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. 2022 Feb 7;12:718776. doi: 10.3389/fmicb.2021.718776

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Copyright © 2022 Parra-Grande, Oré-Arce, Martínez-Priego, D’Auria, Rosselló-Mora, Lillo, Sempere, Lumbreras and Sánchez-Hellín.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Principal component analysis (PCA) of bacteria according to the grade of the tumor (A) and histology (B), at the phylum level. PCA (A) shows the microbial community composition of tumor tissues in relation to high grade (red cicles, n = 29) and low grade (blue triangles, n = 3). PCA (B) shows the microbial community composition of tumor tissues in relation to histology: non-urothelial (red cicles, n = 9) and urothelial (blue triangles, n = 22). Principal component (PC1 and PC2) together, account for 79.5% of the variance in these data.