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. 2022 Feb 7;12:820691. doi: 10.3389/fmicb.2021.820691

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Copyright © 2022 Huang, Li, Zhou, Deng, Zhang, Yi, Zhu, Zhu and Mi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SCFAs supplement enhanced endurance capacity by promoting mitochondrial synthesis. (A) Body weight was measured once a week. (B) Time to exhaustion was recorded. After exhaustion, CK (C), BUN (D), and lactic acid (E) were measured immediately. RT-PCR analysis of mitochondrial biogenesis gene expression (F) and mtDNA content (G) in gastrocnemius. Representative TEM images (H) and quantification (I) of mitochondria in gastrocnemius muscle at original magnification of ×12,000. Data are presented as means ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 (One way ANOVA).