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. 2022 Feb 7;13:821521. doi: 10.3389/fphar.2022.821521

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Copyright © 2022 Chen, Lai, Chen, Ding, Zhou, Su, Ni and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Emodin attenuates cell death, reverses the activation of phosphorylated ERK1/2 and affects synapse-related proteins in SH-SY5Y cells exposed to 300 μM zinc sulfate. (A) The cell death rate determined using the CCK-8 kit. (B) Immunoblot image of phosphorylated ERK1/2 (p-Erk) and total ERK1/2 (t-ERK), synaptophysin, SNAP25, and PSD95 in SH-SY5Y cells. (C) Stain-free image of SH-SY5Y cell lysate. (D, E) Immunoblot analysis of phosphorylated ERK1/2 and total ERK1/2. (F–H) Immunoblot analysis of synapse-related proteins. Different concentrations of emodin (10, 25, and 40 μM) were applied. One-way ANOVA and Bonferroni post hoc analysis, #p < 0.05; Welch’s t test, *p < 0.05 vs. SH-SY5Y cells treated with emodin only; ns, not significant. Data are presented as the mean ± SEM.