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. 2022 Feb 7;13:773288. doi: 10.3389/fimmu.2022.773288

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Copyright © 2022 Figueroa-Romero, Monteagudo, Murdock, Famie, Webber-Davis, Piecuch, Teener, Pacut, Goutman and Feldman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of orally administered tofacitinib on peripheral immune populations in mice. WT control mice (half male and half female) were treated for two weeks with low- (5 mg/kg) and high- (30 mg/kg) dose tofacitinib administered in standard chow. Immune cells were then analyzed in peripheral blood using flow cytometry; (A) percentage of all CD45+ immune cells as well as (B) total numbers of cells was examined for six immune populations. Data show mean ± SEM. Comparisons by ANOVA; n = 4 mice per group. *P<0.05, **P<0.01, ***P<0.001; monos, monocytes.