Table 1.
Subject demographics for primary NK cell analyses.
| Western Blot | Cytokine Gene Expression | Cytokine Protein Secretion | Cytotoxicity | |||||
|---|---|---|---|---|---|---|---|---|
| Control (n = 3) | ALS (n = 4) | Control (n = 3) | ALS (n = 8) | Control (n = 5) | ALS (n = 4) | Control (n = 12) | ALS (n =32) | |
| Age(Mean ± SD) years | 70.5 ± 5.3 | 60.7 ± 13.4 | 66.2 ± 10.9 | 65.0 ± 8.2 | 69.32 ± 3.9 | 65.61 ± 6.7 | 61.7 ± 13.3 | 64.2 ± 9.0 |
| Sex (%) male | 66.6 | 25.0 | 33.3 | 37.5 | 60.0 | 50.0 | 50.0 | 56.3 |
| ALSFRS-R at Blood Draw | N/A | 23.0 ± 7.7 | N/A | 28.4 ± 10.3 | N/A | 35.8 ± 6.1 | N/A | 26.1 ± 8.3 |
| Site of Onset | N/A | Bulbar (50.0%)Cervical (25.0%)Lumbar (25.0%) | N/A | Bulbar (25.0%)Cervical (25.0%)Lumbar (50.0%) | N/A | Bulbar (50.0%)Cervical (25.0%)Lumbar (25.0%) | N/A | Bulbar (18.8%)Cervical (34.4%)Lumbar (46.8%) |
| Race | White (100%)Black (0%)Asian (0%)Not reported (0%) | White (100%)Black (0%)Asian (0%)Not reported (0%) | White (100%)Black (0%)Asian (0%)Not reported (0%) | White (75.0%)Black (25.0%)Asian (0%)Not reported (0%) | White (100%)Black (0%)Asian (0%)Not reported (0%) | White (100%)Black (0%)Asian (0%)Not reported (0%) | White (100%)Black (0%)Asian (0%)Not reported (0%) | White (90.6%)Black (9.4%)Asian (0%)Not reported (0%) |
| Ethnicity | Not Hispanic (100%)Hispanic (0%)Not reported (0%) | Not Hispanic (100%)Hispanic (0%)Not reported (0%) | Not Hispanic (100%)Hispanic (0%)Not reported (0%) | Not Hispanic (100%)Hispanic (0%)Not reported (0%) | Not Hispanic (100%)Hispanic (0%)Not reported (0%) | Not Hispanic (100%)Hispanic (0%)Not reported (0%) | Not Hispanic (100%)Hispanic (0%)Not reported (0%) | Not Hispanic (100%)Hispanic (0%)Not reported (0%) |
| Time from Onset to Collection (Mean ± SD) years | N/A | 5.0 ± 4.2 | N/A | 7.7 ± 6.8 | N/A | 2.7 ± 1.6 | N/A | 4.1 ± 3.9 |
| Time from Diagnosis to Collection (Mean ± SD) years | N/A | 3.6 ± 3.4 | N/A | 5.2 ± 6.7 | N/A | 1.6 ± 1.5 | N/A | 2.7 ± 3.6 |
N/A, not applicable.