Table 3.
Inhibitors of TLS polymerases.
| Inhibitor | TLS polymerase(s) | Effect on cancer cells |
|---|---|---|
| Candesartan cilexetil | Pol η, Pol ι, Pol κ | Sensitises XP-V cells to UV radiation (178) |
| Manoalide; MK-886 | Pol κ | Inhibit Pol κ in vitro but do not sensitise XP-V cells to UV radiation (178) |
| Cholesterol hemisuccinate | Pol η, Pol ι, Pol κ | Not reported (179) |
| Penta-1,2,3,4,6-O-galloyl-beta-D-glucose | Pol η, Pol ι, Pol κ | Not reported (180) |
| Pinophilins A and B | Pol η, Pol ι, Pol κ | Inhibit proliferation of cancer cell lines (181) |
| β-Sitosteryl (6’-O-linoleoyl)-glucoside | Pol η, Pol ι, Pol κ | Not reported (182) |
| 3-O-methylfunicone | Pol ι, Pol κ | Inhibits cervical and colon carcinoma cell growth; sensitises cervical carcinoma cells to UV radiation (183) |
| Penicilliols A and B | Pol η, Pol ι, Pol κ | Not reported (184) |
| PNR-7-02 | Rev 1, Pol η | Sensitises chronic myeloid leukaemia and ovarian cancer cell lines to cisplatin (185) |
| IAG-10 | Pol κ | Sensitises glioblastoma cell lines to temozolomide (186) |
| JH-RE-06 | Rev1 | Sensitises melanoma cells to cisplatin; reduces melanoma tumor volume in mouse model (177, 187) |
| Novobiocin | Pol θ | Synthetic lethality with olaparib in HR-deficient ovarian cancer cells; tumor regression in mouse model (188) |
| ART558; ART812 | Pol θ | Synthetic lethality with olaparib in HR-deficient colon cancer cells; inhibition of HR-deficient tumor xenografts in rat model (189) |