TABLE 2.

Effect of the CR marker on cognitive decline and disease severity in AD spectrum and cognitively unimpaired group.

	AD spectrum			CU
	β	CI	P-value	β	CI	P-value
MMSE
CR marker	1.39	−0.17 ∼ 2.97	0.084	0.89	0.15 ∼ 1.62	0.026
Time	−0.12	−0.16 ∼−0.08	<0.001	−0.02	−0.05 ∼ 0.01	0.26
CR marker × Time	−0.04	−0.08 ∼−0.01	0.026	0.04	0.01 ∼ 0.07	0.017
Composite score
CR marker	5.19	2.20 ∼ 8.21	0.001	5.47	3.25 ∼ 7.65	<0.001
Time	−0.20	−0.28 ∼−0.12	<0.001	−0.18	−0.27 ∼−0.08	0.001
CR marker × Time	−0.08	−0.15 ∼−0.003	0.045	0.20	0.12 ∼ 0.28	<0.001
Memory score
CR marker	7.81	0.35 ∼ 15.32	0.018	8.78	3.91 ∼13.65	0.001
Time	−0.24	−0.37 ∼−0.11	<0.001	−0.47	−0.76 ∼−0.18	0.003
CR marker × Time	−0.14	−0.26 ∼−0.01	0.036	0.39	0.15 ∼ 0.64	0.003
CDR-SB
CR marker	−0.68	−1.58 ∼ 0.22	0.14	−0.10	−0.64 ∼ 0.44	0.72
Time	0.07	0.04 ∼ 0.10	<0.001	0.02	−0.01 ∼ 0.06	0.15
CR marker × Time	0.03	0.01 ∼ 0.06	0.04	−0.02	−0.04 ∼ 0.01	0.23

AD spectrum, Alzheimer’s disease spectrum; CU, cognitively unimpaired group; MMSE, Mini-Mental State Examination; Composite score, the average score of five domains; CDR-SB, Clinical Dementia Rating Scale-Sum of Boxes; β, Beta coefficient of each variable; CI, 95% confidence interval of the beta coefficient; P-value, p-value of each variable in the linear mixed model.