TABLE 4.

Effect of the CR marker on cognitive decline and disease severity (95% confidence intervals from bootstrapping).

	AD spectrum	CU
	95% CIs of β values	95% CIs of β values
MMSE
CR marker	−0.17 ∼ 3.01	0.17 ∼ 1.67
Time	−0.16 ∼−0.08	−0.05 ∼ 0.01
CR marker × Time	−0.08 ∼−0.006	0.01 ∼ 0.07
Composite score
CR marker	2.00 ∼ 8.50	3.47 ∼ 7.47
Time	−0.28 ∼−0.12	−0.26 ∼−0.09
CR marker × Time	−0.15 ∼−0.007	0.13 ∼ 0.27
Memory score
CR marker	1.23 ∼ 14.39	4.31 ∼ 13.79
Time	−0.38 ∼−0.11	−0.75 ∼−0.22
CR marker × Time	−0.27 ∼−0.01	0.14 ∼ 0.62
CDR-SB
CR marker	−1.64 ∼ 0.27	−0.64 ∼ 0.42
Time	0.04 ∼ 0.10	−0.01 ∼ 0.06
CR marker × Time	0.003 ∼ 0.06	−0.05 ∼ 0.01

AD spectrum, Alzheimer’s disease spectrum; CU, cognitively unimpaired group; MMSE, Mini-Mental State Examination; Composite score, the average score of five domains; CDR-SB, Clinical Dementia Rating Scale-Sum of Boxes; β, beta coefficient of each variable; CI, 95% confidence interval of the beta coefficient.