Table 3.

Reclassification analysis of multimarker approaches using PCT, presepsin, and the VACO index for 30-day mortality

Approaches	IDI (95% CI)	P	NRI (95% CI)	P
PCT+VACO index	0.28 (0.04-0.52)	0.022	0.39 (–0.02-0.80)	0.061
Presepsin+VACO index	0.36 (0.15-0.56)	< 0.001	0.47 (0.21-0.73)	< 0.001
PCT+presepsin+VACO index	0.46 (0.24-0.69)	< 0.001	0.64 (0.32-0.95)	< 0.001

IDI and NRI values of multimarker approaches using the above optimal cut-off values of PCT, presepsin, and the VACO index were obtained in comparison with VACO index.

Abbreviations: PCT, procalcitonin; VACO; Veterans Health Administration COVID-19; IDI, integrated discrimination improvement; CI, confidence interval; NRI, net reclassification improvement.