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. 2021 Apr 29;118(3):772–784. doi: 10.1093/cvr/cvab156

Figure 1.

Figure 1

SMC Drebrin attenuates atherosclerosis. The indicated male mice were fed a western diet for 20 weeks, from age 8 weeks: SMC-Dbn−/−/Ldlr−/− mice, and ‘control’ mice [SM22-Cre+/Ldlr−/− (green), Dbnflox/flox/Ldlr−/− (blue), and Dbn+/+/Ldlr−/− (black)]. All control groups yielded congruent data; therefore, data from these groups were pooled. (A) Brachiocephalic artery sections from the indicated mice were stained with H&E; one specimen of each group is shown, representing 9–15 examined per group. Scale bars = 200 μm. (B) Brachiocephalic cross-sectional neointimal and medial areas were measured by planimetry for control (n = 15) and SMC-Dbn−/−/Ldlr−/− mice (n = 9). For each artery, neointimal area was divided by medial area; these ratios for each mouse were plotted along with group means ± S.E. Compared with control mice: *P < 0.001 by t test. (C) Aortas from these mice were excised from the root to the iliac bifurcation, stained with Sudan IV, pinned and photographed en face. Scale bars = 2 mm. (D) The percentage of aortic surface area comprising Sudanophilic lesions was quantitated and plotted for each mouse [control (n = 33) and SMC-Dbn−/−/Ldlr−/− (n = 20)], along with group means ± SE. Compared with control: *P < 0.001 (t test).