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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Cancer Causes Control. 2021 May 20;32(9):1039–1042. doi: 10.1007/s10552-021-01447-9

Table 1.

Hazard ratios (HR) and 95% confidence intervals (95% CI) for hours of sleep and risk of glioma in the UK Biobank and Nurses’ Health Study/Health Professionals Follow-up Study overall, and lagged 2 years.

Glioma subtype UK Biobanka NHS/HPFSb
Overall
No. hours sleep in
24 hour period		 Cases HR (95% CI) p-value Casesc HR (95% CI) p-value
All glioma 7 hours 167 Ref 122 Ref
>7 hours 170 1.05 (0.85-1.30) 0.66 121 1.22 (0.94-1.57) 0.13
< 7 hours 95 0.90 (0.70-1.16) 0.42 71 0.93 (0.69-1.26) 0.65
Ptrendd 0.25 e
GBM 7 hours 120 Ref 86 Ref
>7 hours 127 1.09 (0.84-1.40) 0.52 81 1.15 (0.84-1.56) 0.38
< 7 hours 73 0.96 (0.72-1.29) 0.79 48 0.90 (0.63-1.29) 0.58
Ptrendd 0.39 e
Non-GBM 7 hours 47 Ref 36 Ref
>7 hours 43 0.96 (0.68-1.45) 0.83 40 1.36 (0.86-2.16) 0.19
< 7 hours 22 0.75 (0.45-1.25) 0.27 23 1.00 (0.59-1.70) 0.99
Ptrendd 0.43 e
Lagged 2 years
All glioma 7 hours 123 Ref 105 Ref
>7 hours 133 1.12 (0.88-1.43) 0.37 76 1.31 (1.01-1.69) 0.04
< 7 hours 71 0.92 (0.69-1.24) 0.59 114 1.06 (0.79-1.42) 0.69
Ptrendd 0.17 e
GBM 7 hours 87 Ref 75 Ref
>7 hours 98 1.17 (0.89-1.56) 0.30 50 1.32 (0.97-1.79) 0.08
< 7 hours 56 1.02 (0.73-1.43) 0.89 82 0.98 (0.68-1.40) 0.89
Ptrendd 0.38 e
Non-GBM 7 hours 36 Ref 30 Ref
>7 hours 35 1.00 (0.63-1.60) 0.99 26 1.26 (0.78-2.03) 0.34
< 7 hours 15 0.68 (0.37-1.24) 0.20 32 1.25 (0.75-2.09) 0.39
Ptrendd 0.25 e
a

HR and 95%CIs adjusted for age (5-year age groups), gender, and race (White, non-White, missing).

b

HR and 95%CIs adjusted for age (months), calendar year, cohort (which adjusts for gender), and race (White, non-White, missing, in HPFS).

c

Does not sum to total case count due to missing values for sleep after baseline.

d

Ptrend was calculated using a continuous variable created from the medians within each category of consumption.

e

Unable to calculate due to categorical nature of sleep data. In HPFS, participants were asked to select from the following options for typical sleep in a 24 hour period: <=5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 10.5, or >=11 hours; in NHS, the options were <=5, 6, 7, 8, 9, 10, or >=11 hours.