Table 3.

Risk of glioma in NHS, NHSII, and HPFS by categories of cumulative average total alcohol intake, and separately for alcohol intake from specific beverages, stratified by sex.

			Women (n=343)			Men (n=211)
	Grams Alcohol/Day	Approximate Servings/Week	Cases	MV HRab	95%CI	Cases	MV HRa	95%CI
Total Alcohol	0–0.5	0–0.25	118	Ref.		61	Ref.
	>0.5–2	>0.25–1	70	0.93	0.69–1.25	19	0.58	0.35–0.98
	>2–8	>1–4	91	1.00	0.75–1.32	46	0.63	0.43–0.94
	>8–15	>4–7.5	39	0.90	0.62–1.30	30	0.57	0.36–0.89
	>15	>7.5	25	0.62	0.39–0.97	55	0.79	0.53–1.16
Beer	0–0.5	0–0.25	266	Ref.		119	Ref.
	>0.5–2	>0.25–1	39	0.90	0.64–1.27	38	1.07	0.76–1.51
	>2–8	>1–4	31	1.31	0.89–1.94	35	1.00	0.67–1.47
	>8	>4	7	0.91	0.43–1.94	19	1.04	0.63–1.72
Red Wine	0–0.5	0–0.25	235	Ref.		122	Ref.
	>0.5–2	>0.25–1	70	0.95	0.72–1.24	47	0.97	0.69–1.37
	>2–8	>1–4	35	0.85	0.59–1.22	33	0.94	0.63–1.40
	>8	>4	3	0.52	0.17–1.64	9	1.22	0.61–2.44
White Wine	0–0.5	0–0.25	197	Ref.		113	Ref.
	>0.5–2	>0.25–1	86	0.95	0.74–1.23	62	0.94	0.69–1.29
	>2–8	>1–4	52	0.87	0.64–1.20	24	0.57	0.36–0.89
	>8	>4	8	0.56	0.27–1.15	12	1.30	0.71–2.39
Total Wine	0–0.5	0–0.25	163	Ref.		84	Ref.
	>0.5–2	>0.25–1	93	0.93	0.72–1.20	61	1.10	0.79–1.54
	>2–8	>1–4	68	0.90	0.67–1.20	35	0.61	0.41–0.92
	>8	>4	19	0.60	0.37–0.97	31	1.23	0.80–1.88
Liquor	0–0.5	0–0.25	225	Ref.		112	Ref.
	>0.5–2	>0.25–1	58	1.00	0.74–1.33	38	0.95	0.66–1.39
	>2–8	>1–4	37	1.01	0.70–1.45	25	0.59	0.38–0.92
	>8	>4	23	0.88	0.57–1.38	36	0.95	0.64–1.41

^aAdjusted for age (months), calendar year, smoking status (never vs. past vs. current), BMI (<25 kg/m² vs. ≥25–<30 kg/m² vs. ≥30 kg/m²), and total caloric intake (quintiles).

^bCalculated by fixed effect meta-analysis of NHS and NHSII.

Abbreviations: BMI, body mass index; CI, confidence interval; HPFS, Health Professionals Follow-Up Study; HR, hazard ratio; MV, multivariable; NHS, Nurses’ Health Study; NHSII, Nurses’ Health Study II;