Table 4.
Safety of Common SLE Treatments During Pregnancy and Lactation
| Medication | Pre-Conception | During Pregnancy | Lactation |
|---|---|---|---|
| Compatible | |||
| Hydroxychloroquine | + | + | + |
| Sulfasalazine | + | + | + |
| Azathioprine | + | + | + |
| Cyclosporine | + | + | + |
| Tacrolimus | + | + | + |
| Prednisone | Keep dose <20mg/day | Keep dose <20mg/d | Keep dose <20mg/d |
| NSAIDs | Discontinue w/difficulty conceiving | Stop at week 20 | + |
| Stop at conception | |||
| Belimumab | Stop with positive pregnancy test | + | |
| Rituximab | Stop with positive pregnancy test | + | |
| Abatacept | Stop with positive pregnancy test | + | |
| Not compatible | |||
| Cycophosphamide | Stop 3 mos before conception | X | x |
| MMF/mycophenolic acid | Stop 6 wks before conception | X | x |
| Leflunomide | Cholestyramine washout | X | x |
| Methotrexate | Stop 1 −3mos before conception | x | x- low transfer into breast milk |