Table 2.

Heart rates and drug doses, N = 131 bucindolol, 125 metoprolol

Parameter	M, no. brady episodes	B, no. brady episodes	P value, no. episodes	M, mg/d	B, mg/d	M HR, bpm	B HR, bpm	P value, HR	M mg, % at target†	B mg, % at target†	P value % at target
All rhythms, all pts/ECGs 2–24 weeks	−	−		169 ±57	163 ±59	72.0 ±19.5	76.6 ±17.7	<0.0001	61.7.	74.9	<0.0001
SR, scheduled ECGs only (Figure 2)	−	−		166 ±59	165 ±59	62.6 ±12.5	68.3 ±11.1	<0.0001	−	−	−
AF, Scheduled ECGs only (Figure 2)	−	−		175 ±53	158 ±59	87.5 ±16.4	89.7 ±16.5	0.18	−	−	−
All rhythms, Scheduled ECGs only	−	−		169 ±56	161 ±60	69.2 ±17.1	74.5 ±16.0	<0.0001	−	−	−
At time of any bradycardia episode	261	107	<0.001	142 ±66	153 ±65	51.8 ±6.0	51.9 ±5.6.	0.87	70.9	80.4	0.001
At 1st bradycardia episode	67	38	0.005	163 ±59	149 ±67	52.0 ±8.3	54.4 ±4.7	0.08	81.6	80.9	0.74
At Subsequent bradycardia episodes	194	69	0.001	134 ±68	156 ±64	51.8 ±5.1	50.5 ±5.5	0.12	67.2	80.2	<0.0001
At time of any severe bradycardia episode	71	32	0.001	114 ±66	145 ±57	44.5 ±6.3	44.8 ±3.4	0.80	22.5	50.0	0.011

Target doses mg are M 200 mg/d, B 187 mg/d.

AF = atrial fibrillation; B = bucindolol; bpm = beats per minute; ECG = electrocardiogram; HR = heart rate; M = metoprolol succinate; pts = patients; SR = sinus rhythm.

^†Calculated by determining whether a patient is at target dose at the time of each ECG.