Table 3.

Heart rate ranges, rhythm, and symptom status during the 14 bradycardia adverse events occurring in 12 patients

Treatment group	Heart rate (bpm)
	<40	40–44	45–49	50–54	55–59	≥60	P value, metoprolol vs bucindolol total AEs
Metoprolol	0	1†	5†	3†	2†	2‡	.001
Bucindolol	0	0	1	0	0	0
Linear trend by heart rate bin, metoprolol P = .51; bucindolol P = .80

	Asymptomatic		Symptomatic		−	−	P value, symptomatic vs asymptomatic
	N	Heart rate ± SD	N	Heart rate ± SD	−	−
Metoprolol	8	53.9 ± 10.2	5	63.4 ± 28.7	−	−	Events	Heart Rate
Bucindolol	0	−	1	47	−	−	.43	.57

Heart rates are by the temporally closest electrocardiogram case report available.

AEs = adverse events; bpm = beats per minute.

^†Patients in sinus rhythm.

^‡Patients in atrial fibrillation, rate 77 bpm in 1 asymptomatic patient measured the same day and 1 symptomatic patient at 114 bpm measured 2 weeks before the event.