Table 3:
Linear mixed-effects model results using GE and Helical High Dose protocol as the reference for vendor and protocol, respectively. In this model, CT measurement depends on the true fat-fraction of each vial with fixed effects from vendor and protocol. CT number has high correlation with MRI-PDFF in a relationship with slope of −1.84±0.01 HU/%, intercept of 67.8±2.9 HU, and R2=0.997. CT vendor selection has a significant contribution (p<0.005) to the CT number versus MRI-PDFF calibration relationship (i.e., slope and intercept), however, CT protocol selection has no significant contribution (p>0.1) to the CT number versus MRI-PDFF calibration relationship (i.e., slope and intercept). PDFF, proton density fat-fraction.
Coef. | Std.Err. | p | 95% CI | |||
---|---|---|---|---|---|---|
Slope (HU/%) | Reference (GE) | −1.841 | 0.007 | <0.001 | [−1.855, −1.827] | |
Vendor | Siemens | 0.055 | 0.006 | <0.001 | [0.043, 0.067] | |
Philips | 0.024 | 0.008 | <0.005 | [0.008, 0.040] | ||
Protocol | Axial High Dose | −0.003 | 0.009 | 0.774 | [−0.020, 0.015] | |
Axial Low Dose | −0.001 | 0.009 | 0.968 | [−0.018, 0.017] | ||
Helical Low Dose | 0.004 | 0.009 | 0.685 | [−0.014, 0.021] | ||
AAPM | 0.013 | 0.009 | 0.154 | [−0.005, 0.031] | ||
Intercept (HU) | Reference (Helical High Dose) | 67.8 | 2.9 | <0.001 | [62.1, 73.4] | |
Vendor | Siemens | −5.6 | 0.2 | <0.001 | [−6.0, −5.1] | |
Philips | −3.0 | 0.3 | <0.001 | [−3.6, −2.4] | ||
Protocol | Axial High Dose | −0.1 | 0.3 | 0.798 | [−0.7, 0.6] | |
Axial Low Dose | −0.4 | 0.3 | 0.188 | [−1.1, 0.2] | ||
Helical Low Dose | −0.4 | 0.3 | 0.231 | [−1.1, 0.3] | ||
AAPM | −0.4 | 0.3 | 0.288 | [−1.0, 0.3] |
Note: Coef., coefficient; Std.Err., standard error; 95% CI, 95% confidence interval; AAPM, American Association of Physicists in Medicine.