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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Biopharm Drug Dispos. 2021 Mar 17;42(5):191–203. doi: 10.1002/bdd.2266

FIGURE 1.

FIGURE 1

The minimal physiologically-based pharmacokinetic model with two tissue compartments (single Kp). Blood flow and physiological volumes are used to characterize the distribution spaces and connections among tissue and blood compartments. Symbols are defined in Table 1