TABLE 1.

PK parameters of dexamethasone across 11 species using the joint mPBPK^a

Parameter	Definition	Estimate (CV%)
K p	Tissue to plasma partition coefficient	1.07 (1.93)
f d1	Fraction of QCO for tissue 1	0.85 (1.22)
f d2	Fraction of QCO for tissue 2	0.15b
F t	Fraction of total tissue volume for tissue 1	0.26 (7.50)
F	Bioavailability of intraperitoneal dose in mouse	0.86 (fixed)
k a	Absorption rate constant for mice (h−1)	5 (fixed)

Note: The jointly fitted CL values are listed in Table 5.

Abbreviations: AIC, Akaike Information Criterion; CL, clearance; CV, coefficient of variation; mPBPK, minimal physiologically-based pharmacokinetic; PK, pharmacokinetic.

^aAIC = 1410.4.

^bSecondary parameter: f_d2 = 1 − f_d1.