TABLE 2.
Pharmacokinetic parameters of dexamethasone across 11 species using the joint a2CM with scaling of distribution parametersa
| Parameter | Definition | Estimates (CV%) |
|---|---|---|
| a 1 | Scaling intercept for Vcen | 1.12 (14.76) |
| b 1 | Scaling exponent for Vcen | 0.88 (1.77) |
| a 2 | Scaling intercept for Vper | 0.13 (27.18) |
| b 2 | Scaling exponent for Vper | 1.13 (2.00) |
| a 3 | Scaling intercept for CLD | 1.02 (52.85) |
| b 3 | Scaling exponent for CLD | 0.92 (4.82) |
| F | Bioavailability of intraperitoneal dose | 0.86 (fixed) |
| k a | Absorption rate constant for mouse (1/h) | 5 (fixed) |
Note: The jointly fitted CL values are listed in Table 5.
Abbreviations: AIC, Akaike Information Criterion; a2CM, allometric two-compartment model; CL, clearance; CV, coefficient of variation.
a
AIC = 1422.9.