TABLE 4.
Summary of literature data for the pharmacokinetics of dexamethasone in man
| Reference | Subjects Sex | Type of subjects | Assay method | Dosing route | Dose (mg) | CL (L/h/kg) | Vss (L/kg) |
|---|---|---|---|---|---|---|---|
| Duggan et al. (1975) | 11 M | Healthy | RIA | IV | 12 | 0.130 | |
| Hare et al. (1975) | 9 | Healthy | RIA | IV | 1 mg/kg | 0.168 | |
| Tsuei et al. (1979) | 6 F, 6 M | Healthy | HPLC | IV | 6.66 | 0.210 | 0.75 |
| Rose et al. (1981) | 8 M | Healthy | RIA | IV | 4 | 0.177 | 1.08 |
| Miyabo et al. (1981) | 10 M | Healthy | RIA | IV | 20 | 0.188 | |
| Loew et al. (1986) | 10 F | Healthy | RIA | IM | 3 | 0.141 | 1.00 |
| Workman et al. (1986) | 6 | Healthy | RIA | IV | 1 | 0.111 | 0.58 |
| Rohdewald et al. (1987) | 7 M, 3 F | Healthy | RIA | IV | 15 | 0.079 | 1.20 |
| Braat et al. (1992) | 10 M | Healthy | HPLC | IV | 3.8 | 0.300 | 1.32 |
| O’Sullivan et al. (1997) | 5 M, 5 F | Healthy | RIA | IV | 1 | 0.108 | 0.64 |
| Hochhaus et al. (2001) | 10 M | Healthy | RIA | IV | 8.3 | 0.225 | 1.40 |
| Mager et al. (2003) | 5 M | Healthy | HPLC | IV | 6 | 0.247 | 1.50 |
| Jobe et al. (2020) | 12 F | Healthy | LC-MS/MS | IM | 6 | 0.160 | 1.18 |
Abbreviations: CL, clearance; F, female; HPLC, high-performance liquid chromatography; LC-MS/MS, liquid chromatography with mass spectroscopy/mass spectroscopy; M, male; RIA, radioimmunoassay.