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. 2022 Feb 7;12:823667. doi: 10.3389/fonc.2022.823667

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Copyright © 2022 Roden, Rakshit, Johnson, Jenkins and Mansfield

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Patient #8. (A) A computed tomography scan shows a prevascular mediastinal lesion (arrow) that takes up 68Ga on a DOTATATE PET scan which was interpreted as Krenning score 3 (B). (C) The resection specimen shows sheets and nests of neoplastic cells (right side) in a background of thymic gland (left side). (D) The neoplastic cells are round with high nuclear-to-cytoplasmic ratio and high mitotic activity. The neoplastic cells are positive for keratin CAM5.2 (focal), synaptophysin, chromogranin (focal), and TTF-1 and negative for p63; Ki-67 shows a high proliferative index (stains not shown). (E) SSTR2 expression is diffuse and strong in virtually all tumor cells in a membranous and cytoplasmic expression pattern (F). Magnification, H&E x 20 (C), x 400 (D), SSTR2 x 40 (E), x 400 (F).