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. Author manuscript; available in PMC: 2022 Feb 21.
Published in final edited form as: J Med Chem. 2018 May 14;61(12):5162–5186. doi: 10.1021/acs.jmedchem.7b01862

Figure 5.

Figure 5.

Activity of DHODH inhibitors in a leukemia cell line. (A) IC50 values of select analogues in HL-60. Compounds were assayed for antiproliferative effects in an MTT assay containing complete medium. (B) Uridine supplementation rescues cell growth inhibition induced by select optimized analogues. Compounds were assayed at twice their IC50 values for antiproliferative effects in an MTT assay with medium containing dialyzed FBS ± 5 μM uridine. Data are represented as the mean and standard deviation from three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.005, # p < 0.001.