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. 2022 Feb 7;9:826248. doi: 10.3389/fcell.2021.826248

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Copyright © 2022 Fader Kaiser, Romano, Vanrell, Pocognoni, Jacob, Caruso and Delgui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The regulatory mechanism of LD in cancer progression. Different signaling pathways of lipid acquisition may drive LD biogenesis in stressed cancer cells. Increased LD contents could expand the source of lipid substrates and energy to meet the metabolic needs of proliferating cancer cells. In the tumor microenvironment, LD could act as an energy reservoir for an aggressive cancer to trigger metastatic cloning. LD accumulation extensively mediates proliferation, invasion, metastasis, and oxidative stress and chemotherapy resistance in multiple types of cancers.