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. 2022 Feb 15;5(5):e202101114. doi: 10.26508/lsa.202101114

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© 2022 Zhang et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 1. — Balloon-injured rat left common carotid arteries and contralateral arteries (uninjured sham control) were collected (each group pooled from 50 rats) at day 7 post angioplasty and snap-frozen for use in ChIPseq experiments. (A) ChIPseq heat map showing binding density of BRD4, H3K27ac, H3K27me3, or H3K4me1. ChIPseq signal anchors a 10 kb center region with 5 kb flanking on either side of the transcription start site. Hierarchical clustering highlights injury-induced increase of H3K27me3 ChIPseq signal (Cluster-1) and non-overlap between H3K27me3 and H3K27ac. (B) Functional enrichment of Clusters 1 and 2. Presented is dot plot of Top 10 molecular function (MF) gene ontology (GO) terms with color as adjusted P-value and size of dot as gene ratio. Enrichment analysis was performed by clusterProfiler.