Castelao 1993.

Methods	Study design: parallel RCT Time frame: NS Follow‐up: NS
Participants	Setting: NS Country: Spain KTR Number: treatment group 1 (25); treatment group 2 (26) Mean age ± SD (years): treatment group 1 (44 ± 10); treatment group 2 (43 ± 11) Sex (males): treatment group 1 (64%); treatment group 2 (73.1%) Exclusion criteria: patients on statins; hepatitis; myopathy; serum TG > 4.5 mmol/L
Interventions	Treatment group 1 Lovastatin 20 mg/d Treatment group 2 Simvastatin 10 mg/d
Outcomes	Lipid parameters (TC, LDL, HDL, TG) Safety outcomes (hepatic and muscle toxicity)
Notes	Publication type: Journal publication
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	High risk	Unblinded
Blinding of outcome assessment (detection bias) All outcomes	High risk	Not clearly described
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Not clearly described; no withdrawals
Intention to treat analysis	Unclear risk	Not described