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. 2022 Feb 7;16:769347. doi: 10.3389/fncel.2022.769347

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Copyright © 2022 Womack, Vollert, Ohia-Nwoko, Schmitt, Montazari, Beckett, Mayerich, Murphy and Eriksen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increase of neuroinflammation in APdE9/CP-Tg mice. Quantification of activated microglia, measured by Iba 1 staining, in the cortex of 17–20-month-old NTg, CP-TG, APdE9, and APdE9/CP-Tg mice. (A) Representative two-dimensional images of Iba 1-positive microglia in whole coronal brain slices. Scale bar = 50 μm. (B) Prostacyclin overexpression in the APdE9 mouse model significantly increases neuroinflammation measured by the presence of hyperactivated microglia in brain tissues. *p < 0.05 compared to NTg mice. n = 4−5 mice per group.