Figure 2.

Prostacyclin overexpression increased anxiety-like behavior as measured by light-dark and elevated plus-maze tests. (A) CP-Tg and APdE9/CP-Tg mice spent significantly less time in the light during light-dark exploration. (B) In the elevated plus-maze, all transgenic mouse lines spent significantly less time in the lit arms and made fewer transitions between the open and closed arms (C) of the elevated plus-maze. Bars are means ± SEM, n = 8–10 mice per group. *p < 0.05 compared to NTg mice.