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. 2022 Feb 7;16:769347. doi: 10.3389/fncel.2022.769347

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Copyright © 2022 Womack, Vollert, Ohia-Nwoko, Schmitt, Montazari, Beckett, Mayerich, Murphy and Eriksen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prostacyclin overexpression enhances motor learning and coordination. In 14–17-month-old mice, both CP-Tg and APdE9/CP-Tg mice showed improved coordination on the rotarod, compared with NTg and APdE9 mice on trials 7 and 8. Bars are means ± SEM, n = 7–8 mice per group. *p < 0.05 compared to NTg and APdE9 mice.