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. 2022 Feb 7;16:769347. doi: 10.3389/fncel.2022.769347

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Copyright © 2022 Womack, Vollert, Ohia-Nwoko, Schmitt, Montazari, Beckett, Mayerich, Murphy and Eriksen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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APdE9/CP-Tg mice exhibit impaired learning. (A) PGIS overexpression significantly decreased the percentage freezing time after the first and second shock (shock given at 2nd and 4th min) of the training trial (p < 0.05) while the combination of Aβ and prostacyclin further decreased freezing times during training. (B) APdE9 mice exhibited an enhanced short-term memory response while APdE9/CP-Tg mice exhibited a depressed short-term memory response. (C) CP-Tg and APdE9/CP-Tg mice exhibited worse performance in a contextual test of long-term memory compared to APdE9 mice. (D) CP-Tg and APdE9/CP-Tg mice showed an initial delay in freezing at the 2nd min; however, no significant differences were observed after application of the 3-min tone from minute 3 to 6 in a cued assessment of long-term memory. N = 7–14 mice per group. *p < 0.05 compared to NTg mice. PGIS, PGI2 synthase.