Table 3.

Randomized Controlled Trials on Local Use of Tranexamic Acid in Soft-Tissue Surgery: Inner Organs, Open Surgery

Reference, Year, Publication Type	TXA Group (total sample size)	Procedure	Concentration of TXA, Volume, Mode of Administration	Comparator	Bleeding *	Postoperative Hemorrhagic Incidence/Intervention/Transfusion †
Sabry 2018, article64	35 (70)	Lung decortication	30 mg/ml, 100 ml, poured into pleural cavity, drains clamped for 30–45 minutes	100 ml saline as placebo	Postoperative blood loss drain production at 48 h (ml); TXA = 383 ± 120 vs placebo = 633 ± 164	Transfusion need (units of transfused blood) mean ± SD: TXA = 0.7 ± 0.9 vs placebo = 1.5 ± 1.1
Sallam 2019, article65	43 (86)	Open hysterectomy	20 mg/ml, 50 ml irrigation, 50 ml intraabdominally	50 + 50 ml saline as placebo	Total blood loss (ml) TXA 395 ± 118 vs placebo 609 ± 119, p < 0.001	Transfusion need (n): TXA = 2 vs placebo = 4
Shady 2018, article66	35 (70)	Open myomectomy	20 mg/ml, 100 ml, soaked gauze for 5 minutes	100 ml saline as placebo	Total blood loss (ml) TXA = 684 ± 215 vs placebo = 1080 ± 126, p < 0.001	Transfusion need (n): TXA = 7 vs placebo = 19
Pourfakhr 2016, article63	186 total	Prostatectomy	100 mg/ml, 5ml, topical irrigation after resection	5 ml saline as placebo	Total blood loss (ml) TXA = 340 ± 152 vs placebo 515 ± SD not given, p = 0.01	Transfusion need (n): TXA = 0 vs placebo = 5

TXA, tranexamic acid; SD, standard deviation.

^*Values are mean unless otherwise stated.

^†Values (n) are number of patients unless otherwise stated.