TABLE 1.
CPA1 Immunostaining in Tumors
| CPA1 Immunostaining | |||||||
|---|---|---|---|---|---|---|---|
| Tumor Entity | On TMA (n) | Analyzable (n) | Negative (%) | Weak (%) | Moderate (%) | Strong (%) | |
| Tumors of the skin | Pilomatrixoma | 35 | 32 | 100 | 0 | 0 | 0 |
| Basal cell carcinoma | 88 | 56 | 100 | 0 | 0 | 0 | |
| Benign nevus | 29 | 26 | 100 | 0 | 0 | 0 | |
| Squamous cell carcinoma of the skin | 90 | 82 | 100 | 0 | 0 | 0 | |
| Malignant melanoma | 48 | 44 | 100 | 0 | 0 | 0 | |
| Merkel cell carcinoma | 46 | 44 | 100 | 0 | 0 | 0 | |
| Tumors of the head and neck | Squamous cell carcinoma of the larynx | 110 | 96 | 100 | 0 | 0 | 0 |
| Squamous cell carcinoma of the pharynx | 60 | 46 | 100 | 0 | 0 | 0 | |
| Oral squamous cell carcinoma (floor of the mouth) | 130 | 118 | 100 | 0 | 0 | 0 | |
| Pleomorphic adenoma of the parotid gland | 50 | 44 | 100 | 0 | 0 | 0 | |
| Warthin tumor of the parotid gland | 104 | 91 | 100 | 0 | 0 | 0 | |
| Adenocarcinoma, not otherwise specified (NOS) (papillary cystadenocarcinoma) | 14 | 12 | 100 | 0 | 0 | 0 | |
| Salivary duct carcinoma | 15 | 12 | 100 | 0 | 0 | 0 | |
| Acinic cell carcinoma of the salivary gland | 181 | 128 | 100 | 0 | 0 | 0 | |
| Adenocarcinoma NOS of the salivary gland | 109 | 69 | 100 | 0 | 0 | 0 | |
| Adenoid cystic carcinoma of the salivary gland | 180 | 99 | 100 | 0 | 0 | 0 | |
| Basal cell adenocarcinoma of the salivary gland | 25 | 21 | 100 | 0 | 0 | 0 | |
| Basal cell adenoma of the salivary gland | 101 | 86 | 100 | 0 | 0 | 0 | |
| Epithelial-myoepithelial carcinoma of the salivary gland | 53 | 51 | 100 | 0 | 0 | 0 | |
| Mucoepidermoid carcinoma of the salivary gland | 343 | 239 | 100 | 0 | 0 | 0 | |
| Myoepithelial carcinoma of the salivary gland | 21 | 20 | 100 | 0 | 0 | 0 | |
| Myoepithelioma of the salivary gland | 11 | 9 | 100 | 0 | 0 | 0 | |
| Oncocytic carcinoma of the salivary gland | 12 | 12 | 100 | 0 | 0 | 0 | |
| Polymorphous adenocarcinoma, low grade, of the salivary gland | 41 | 32 | 100 | 0 | 0 | 0 | |
| Pleomorphic adenoma of the salivary gland | 53 | 32 | 100 | 0 | 0 | 0 | |
| Tumors of the lung, pleura, and thymus | Adenocarcinoma of the lung | 246 | 160 | 100 | 0 | 0 | 0 |
| Squamous cell carcinoma of the lung | 130 | 65 | 100 | 0 | 0 | 0 | |
| Small cell carcinoma of the lung | 20 | 16 | 100 | 0 | 0 | 0 | |
| Mesothelioma, epitheloid | 39 | 32 | 100 | 0 | 0 | 0 | |
| Mesothelioma, other types | 76 | 63 | 100 | 0 | 0 | 0 | |
| Thymoma | 29 | 29 | 100 | 0 | 0 | 0 | |
| Tumors of the female genital tract | Squamous cell carcinoma of the vagina | 78 | 63 | 100 | 0 | 0 | 0 |
| Squamous cell carcinoma of the vulva | 130 | 116 | 100 | 0 | 0 | 0 | |
| Squamous cell carcinoma of the cervix | 130 | 124 | 100 | 0 | 0 | 0 | |
| Endometrioid endometrial carcinoma | 236 | 223 | 100 | 0 | 0 | 0 | |
| Endometrial serous carcinoma | 82 | 72 | 100 | 0 | 0 | 0 | |
| Carcinosarcoma of the uterus | 48 | 38 | 100 | 0 | 0 | 0 | |
| Endometrial carcinoma, high grade, G3 | 13 | 13 | 100 | 0 | 0 | 0 | |
| Endometrial clear cell carcinoma | 8 | 7 | 100 | 0 | 0 | 0 | |
| Endometrioid carcinoma of the ovary | 110 | 91 | 100 | 0 | 0 | 0 | |
| Serous carcinoma of the ovary | 559 | 462 | 100 | 0 | 0 | 0 | |
| Mucinous carcinoma of the ovary | 96 | 71 | 100 | 0 | 0 | 0 | |
| Clear cell carcinoma of the ovary | 50 | 40 | 100 | 0 | 0 | 0 | |
| Carcinosarcoma of the ovary | 47 | 38 | 100 | 0 | 0 | 0 | |
| Brenner tumor | 9 | 9 | 100 | 0 | 0 | 0 | |
| Tumors of the breast | Invasive breast carcinoma of no special type | 1391 | 1185 | 100 | 0 | 0 | 0 |
| Lobular carcinoma of the breast | 294 | 236 | 100 | 0 | 0 | 0 | |
| Medullary carcinoma of the breast | 26 | 26 | 100 | 0 | 0 | 0 | |
| Tubular carcinoma of the breast | 27 | 26 | 100 | 0 | 0 | 0 | |
| Mucinous carcinoma of the breast | 58 | 44 | 100 | 0 | 0 | 0 | |
| Phyllodes tumor of the breast | 50 | 47 | 100 | 0 | 0 | 0 | |
| Tumors of the digestive system | Adenomatous polyp, low-grade dysplasia | 50 | 49 | 100 | 0 | 0 | 0 |
| Adenomatous polyp, high-grade dysplasia | 50 | 49 | 100 | 0 | 0 | 0 | |
| Adenocarcinoma of the colon | 956 | 721 | 100 | 0 | 0 | 0 | |
| Gastric adenocarcinoma, diffuse type | 226 | 129 | 100 | 0 | 0 | 0 | |
| Gastric adenocarcinoma, intestinal type | 224 | 134 | 100 | 0 | 0 | 0 | |
| Gastric adenocarcinoma, mixed type | 62 | 47 | 100 | 0 | 0 | 0 | |
| Adenocarcinoma of the esophagus | 133 | 60 | 100 | 0 | 0 | 0 | |
| Squamous cell carcinoma of the esophagus | 124 | 42 | 100 | 0 | 0 | 0 | |
| Squamous cell carcinoma of the anal canal | 91 | 78 | 100 | 0 | 0 | 0 | |
| Cholangiocarcinoma | 114 | 108 | 100 | 0 | 0 | 0 | |
| Hepatocellular carcinoma | 50 | 50 | 100 | 0 | 0 | 0 | |
| Ductal adenocarcinoma of the pancreas | 662 | 449 | 100 | 0 | 0 | 0 | |
| Pancreatic/Ampullary adenocarcinoma | 119 | 75 | 100 | 0 | 0 | 0 | |
| Acinar cell carcinoma of the pancreas | 11 | 11 | 0 | 0 | 18.2 | 81.8 | |
| Mixed acinar endocrine carcinoma of the pancreas | 1 | 1 | 0 | 0 | 0 | 100 | |
| Gastrointestinal stromal tumor (GIST) | 50 | 49 | 100 | 0 | 0 | 0 | |
| Tumors of the urinary system | Urothelial carcinoma, pT2-4 G3 | 1207 | 613 | 100 | 0 | 0 | 0 |
| Small cell neuroendocrine carcinoma of the bladder | 18 | 18 | 100 | 0 | 0 | 0 | |
| Sarcomatoid urothelial carcinoma | 25 | 24 | 100 | 0 | 0 | 0 | |
| Clear cell renal cell carcinoma | 858 | 759 | 100 | 0 | 0 | 0 | |
| Papillary renal cell carcinoma | 255 | 208 | 100 | 0 | 0 | 0 | |
| Clear cell (tubulo) papillary renal cell carcinoma | 21 | 19 | 100 | 0 | 0 | 0 | |
| Chromophobe renal cell carcinoma | 131 | 118 | 100 | 0 | 0 | 0 | |
| Oncocytoma | 177 | 147 | 100 | 0 | 0 | 0 | |
| Tumors of the male genital organs | Adenocarcinoma of the prostate, Gleason 3+3 | 83 | 79 | 100 | 0 | 0 | 0 |
| Adenocarcinoma of the prostate, Gleason 4+4 | 80 | 73 | 100 | 0 | 0 | 0 | |
| Adenocarcinoma of the prostate, Gleason 5+5 | 85 | 80 | 100 | 0 | 0 | 0 | |
| Adenocarcinoma of the prostate (recurrence) | 261 | 231 | 100 | 0 | 0 | 0 | |
| Small cell neuroendocrine carcinoma of the prostate | 17 | 16 | 100 | 0 | 0 | 0 | |
| Seminoma | 621 | 444 | 100 | 0 | 0 | 0 | |
| Embryonal carcinoma of the testis | 50 | 39 | 100 | 0 | 0 | 0 | |
| Yolk sack tumor | 50 | 32 | 100 | 0 | 0 | 0 | |
| Teratoma | 50 | 44 | 100 | 0 | 0 | 0 | |
| Squamous cell carcinoma of the penis | 80 | 66 | 100 | 0 | 0 | 0 | |
| Tumors of endocrine organs | Adenoma of the thyroid gland | 114 | 108 | 100 | 0 | 0 | 0 |
| Papillary thyroid carcinoma | 392 | 361 | 100 | 0 | 0 | 0 | |
| Follicular thyroid carcinoma | 158 | 147 | 100 | 0 | 0 | 0 | |
| Medullary thyroid carcinoma | 107 | 100 | 100 | 0 | 0 | 0 | |
| Anaplastic thyroid carcinoma | 45 | 43 | 100 | 0 | 0 | 0 | |
| Adrenal cortical adenoma | 50 | 44 | 100 | 0 | 0 | 0 | |
| Adrenal cortical carcinoma | 26 | 26 | 100 | 0 | 0 | 0 | |
| Phaeochromocytoma | 50 | 50 | 100 | 0 | 0 | 0 | |
| Appendix, neuroendocrine tumor (NET) | 22 | 12 | 100 | 0 | 0 | 0 | |
| Colorectal, NET | 11 | 10 | 100 | 0 | 0 | 0 | |
| Ileum, NET | 49 | 46 | 100 | 0 | 0 | 0 | |
| Lung, NET | 19 | 17 | 100 | 0 | 0 | 0 | |
| Pancreas, NET | 98 | 87 | 100 | 0 | 0 | 0 | |
| Colorectal, NEC | 12 | 10 | 100 | 0 | 0 | 0 | |
| Gallbladder, NEC | 4 | 4 | 100 | 0 | 0 | 0 | |
| Pancreas, NEC | 14 | 14 | 100 | 0 | 0 | 0 | |
| Tumors of hematopoietic and lymphoid tissues | Hodgkin lymphoma | 103 | 76 | 100 | 0 | 0 | 0 |
| Non-Hodgkin lymphoma | 62 | 54 | 100 | 0 | 0 | 0 | |
| Small lymphocytic lymphoma, B-cell type (B-SLL/B-CLL) | 50 | 30 | 100 | 0 | 0 | 0 | |
| Diffuse large B-cell lymphoma (DLBCL) | 114 | 94 | 100 | 0 | 0 | 0 | |
| Follicular lymphoma | 88 | 63 | 100 | 0 | 0 | 0 | |
| T-cell non-Hodgkin lymphoma | 24 | 16 | 100 | 0 | 0 | 0 | |
| Mantle cell lymphoma | 18 | 13 | 100 | 0 | 0 | 0 | |
| Marginal zone lymphoma | 16 | 10 | 100 | 0 | 0 | 0 | |
| DLBCL in the testis | 16 | 13 | 100 | 0 | 0 | 0 | |
| Burkitt lymphoma | 5 | 1 | 100 | 0 | 0 | 0 | |
| Tumors of soft tissue and bone | Tenosynovial giant cell tumor | 45 | 44 | 100 | 0 | 0 | 0 |
| Granular cell tumor | 53 | 44 | 100 | 0 | 0 | 0 | |
| Leiomyoma | 50 | 48 | 100 | 0 | 0 | 0 | |
| Leiomyosarcoma | 87 | 84 | 100 | 0 | 0 | 0 | |
| Liposarcoma | 132 | 129 | 100 | 0 | 0 | 0 | |
| Malignant peripheral nerve sheath tumor (MPNST) | 13 | 11 | 100 | 0 | 0 | 0 | |
| Myofibrosarcoma | 26 | 26 | 100 | 0 | 0 | 0 | |
| Angiosarcoma | 73 | 66 | 100 | 0 | 0 | 0 | |
| Angiomyolipoma | 91 | 91 | 100 | 0 | 0 | 0 | |
| Dermatofibrosarcoma protuberans | 21 | 18 | 100 | 0 | 0 | 0 | |
| Ganglioneuroma | 14 | 13 | 100 | 0 | 0 | 0 | |
| Kaposi sarcoma | 8 | 6 | 100 | 0 | 0 | 0 | |
| Neurofibroma | 117 | 96 | 100 | 0 | 0 | 0 | |
| Sarcoma, NOS | 75 | 59 | 100 | 0 | 0 | 0 | |
| Paraganglioma | 41 | 37 | 100 | 0 | 0 | 0 | |
| Primitive neuroectodermal tumor (PNET) | 23 | 18 | 100 | 0 | 0 | 0 | |
| Rhabdomyosarcoma | 7 | 7 | 100 | 0 | 0 | 0 | |
| Schwannoma | 121 | 106 | 100 | 0 | 0 | 0 | |
| Synovial sarcoma | 12 | 11 | 100 | 0 | 0 | 0 | |
| Osteosarcoma | 43 | 35 | 100 | 0 | 0 | 0 | |
| Chondrosarcoma | 38 | 17 | 100 | 0 | 0 | 0 | |
All reclassified cases are included in this table. All positive cases are highlighted in gray.