Skip to main content
. 2022 Feb 3;145(8):606–619. doi: 10.1161/CIRCULATIONAHA.121.054347

Figure 1.

Figure 1.

Pedigree and electrophysiological abnormalities found in a family with atypical Holt–Oram syndrome with early onset AF. A, Pedigree showing the presence of skeletal abnormalities, congenital heart disease (ie, septal defects) and AF in TBX5p.G125R carriers. B through E, Example ECG traces of electrophysiological abnormalities found within 1 individual with the TBX5p.G125R variant (Patient II-5; Table S1). AF indicates atrial fibrillation; AV, atrioventricular; CHD, congenital heart disease; and TBX5, T-box transcription factor 5.