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. 2022 Feb 7;13:798471. doi: 10.3389/fimmu.2022.798471

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Copyright © 2022 Chen, Zhang, Jiang, Wang, Guo, Gao, Zhang, Wang and Zheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The landscape of the tumor immune microenvironment in different FB-based clusters. (A) Comparison of the abundances of 22 immune cells in different subclusters. (B) Expression of chemokines, interleukins, interferons, MHC molecules, co-stimulators, co-inhibitors, and other important cytokines and their receptors in ccRCC from different subclusters. (C) Different values of vital immune characteristics in different subclusters. ccRCC, clear cell renal cell carcinoma; TCR, T cell receptor; CTA, cancer testis antigens; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, non-significance.