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. 2022 Feb 7;13:813626. doi: 10.3389/fphys.2022.813626

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Copyright © 2022 Li, Wang, Dang, Yao, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Osthole treatment changed serum metabolites in chronic constriction injury (CCI) mice. (A) Total ion flow of mice in each group under positive and negative ion mode. (B) PLS-DA 2D and 3D diagram. (C) OPLS-DA analysis. (D) The variable important for the project (VIP) value of differentially expressed MS2 metabolites.