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. 2022 Feb 21;45(4):1631–1650. doi: 10.1007/s10753-022-01647-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Gene expression of inflammasome components in intestinal mucosa of CD patients. Ileum from CD ileitis patients or colon from CD colitis patients (CD Cohort 1) with matching ileal/colonic control samples (Controls for CD cohort 1) were analyzed by RT-PCR. Gene expression was normalized to the housekeeping gene RPLP0 and data are shown as relative fold change to control (Ctr) using the 2^−ΔΔCT method. (a) Schematic representation of components forming an inflammasome. (b–d) Gene expression of significantly differentially expressed sensors, effectors, and LRRK2, for either ileum (upper rows) or colon (lower rows) among the genes examined (Online Resource Table S1) is shown. Bar height shows the median. Ctr ileum n = 8; CD ileum n = 10; Ctr colon n = 10; CD colon n = 7. Significance was assessed by Mann–Whitney U test, *p < 0.05, **p < 0.005, ***p < 0.0005.