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. 2022 Feb 21;45(4):1631–1650. doi: 10.1007/s10753-022-01647-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — NLRP3-related genes are broadly activated in CD ileitis. Gene expression in ileal samples from CD cohort 2 and Controls for CD cohort 2 (Ctr) were analyzed using quantitative NanoString nCounter technology. Expression was normalized to the housekeeping gene pool and positive controls (by nCounter technology). (a) Expression of differentially expressed inflammasome-related genes in ileum is shown. Significance was assessed by Mann–Whitney U test, *p < 0.05, **p < 0.005. Data are shown as median IQR. NLRP3-related genes are indicated with a yellow box. (b) Linear regression plots show Pearson correlation of the indicated genes’ relative abundance with disease activity (Harvey Bradshaw Index). Ctr n = 5, CD n = 7.