Table 3. Correlation between the frequency of CD4+, CD8+, histopathological characteristics, and PD-L1 immunoexpression in LLSCC cases.
| Variáveis | CD4lowCD8low | CD4lowCD8high | CD4high CD8high | CD4highCD8low | |
|---|---|---|---|---|---|
| Gradation | |||||
| WD | 2 | 0 | 5 | 2 | |
| MD | 2 | 2 | 1 | 0 | |
| PD | 1 | 0 | 2 | 0 | |
| Inflammatory Infiltrate | |||||
| Mild | 3 | 1 | 1 | 1 | |
| Moderade | 1 | 1 | 0 | 1 | |
| Intense | 1 | 1 | 3 | 0 | |
| TILsa (χ2 = 8.467; p < 0.05) | |||||
| 0% - 40% | 5 | 2 | 4 | 1 | |
| 41% - 90% | 0 | 1 | 5 | 2 | |
| PD-L1b (χ2 = 7.600; p < 0.05) | |||||
| Positive | 0 | 1 | 3 | 2 | |
| Negative | 5 | 1 | 5 | 0 | |
| TOTAL | 5 | 2 | 8 | 2 | |
a
TILs vs. CD4-CD8 groups;
b
PD-L1 vs. CD4-CD8 groups.
Abbreviations: LLSCC, lower lip squamous cell carcinoma; MD, moderately-differentiated; PD, poorly-differentiated; PD-L1, Programmed death ligand-1; TILs, Tumor infiltrate lymphocytes; WD, well differentiated. p-value < 0.05 considered statistically significant. χ2-value: chi-square.