Table 5.
Grade evidence profile: Association between tooth loss and ischemic stroke.
| Certainty assessment | Summary of findings | Certainty | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| № of patients | Effect | ||||||||||
| No of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Tooth loss | Control | Relative soft-enter (95% CI) | Absolute soft-enter (95% CI) | |
| 4 | Cohort studies | Not serious | Not serious | Not serious | Not serious | Strong association, soft-enter dose response gradient | 7290/485134 (1.5%) | 24867/4138665 (0.6%) | RR 2.58 soft-enter (2.39 to 2.79) | 9 more per 1,000 soft-enter (from 8 more to 11 more) | ⊕⊕⊕⊕ |
| High | |||||||||||
| 3 | Case-control studies | Not serious | Seriousa | Not serious | Not serious | Strong association | 931 cases 784 controls | MD-4.15 soft-enter (−6.09 to −2.22) | 0 fewer per 1,000 soft-enter (from 0 fewer to 0 fewer) | ⊕⊕○○ | |
| Low | |||||||||||
| — | 0% | ||||||||||
Notes: a. Considerable heterogeneity (I2 = 77%). Abbreviations: CI: confidence interval; RR: risk ratio.