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. 2022 Jan 21;50(3):1335–1350. doi: 10.1093/nar/gkac024

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Pan-cancer and breast cancer GWAS analysis. (A) GWAS variants associated to all cancer types annotated as enhancers, active enhancers and promoters compared with random sets of variants. (B) Same as A) but with GWAS variants associated to breast cancer risk. (C) Cancer related TFs over-represented in breast cancers GWAS variants with respect to random sets in ChIP-seq data and TFBS motif alterations. Red P-values <0.01, blue P-values >0.01, white no data. (D) Cancer related terms resulting from the gene set enrichment analysis on all transcription factors over-represented for ChIP-seq and with TFBS motif alterations.