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In vivo metabolic stability of siRNA is dependent on stereochemistry of terminal PS linkages. Mice (n = 3) were treated with single subcutaneous injections of 2.5 mg/kg C5-targeted and 2 mg/kg for Ttr-targeted siRNAs. After 5 and 7 days, respectively, liver levels of sense and antisense siRNA were quantified by stem-loop RT-qPCR.
