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. 2021 Jul 15;50(3):1221–1240. doi: 10.1093/nar/gkab544

Figure 11.

Figure 11.

Environments of the 5′- and 3′-terminal phosphate groups of the antisense siRNA strand bound to Ago proteins. (A) The region of the 5′ terminus of the antisense strand bound to the MID domain of human Ago2 (PDB ID: 4F3T). P1 is the 5′ phosphate; P2 is the first bridging phosphate. (B) The region of the 3′-terminal end of the antisense strand bound to the PAZ domain of human Ago1 (PDB ID: 1SI3). P23 is the terminal linkage. (C) The region of the 3′-terminal end of the antisense strand bound to the PAZ domain of human Ago2 (PDB ID: 4F3T). P23 is the terminal linkage. Selected residues are labeled. Hydrogen bonds are drawn with thin solid lines, and further contacts are indicated with dashed lines with distances in Å. The illustrations were generated with the program UCSF Chimera (63).