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. 2021 Jul 15;50(3):1221–1240. doi: 10.1093/nar/gkab544

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — (A) The general design of approved GalNAc conjugates with six PS linkages indicating the chemical modifications employed. Chemical modifications other than the terminal PS linkages and GalNAc are for illustration purposes only. (B) The design and sequence of GalNAc conjugates described in this work that are modified with three PS linkages. Green nucleotide background indicates 2′-F; black background indicates 2′-OMe. Orange lines indicate location of PS linkages. Blue hexagons represent triantennary GalNAc.