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. 2021 Jul 15;50(3):1221–1240. doi: 10.1093/nar/gkab544

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — In vivo evaluation of C5-targeting siRNAs containing stereo-defined PS linkages at the termini compared to stereo-random controls. Female C57BL/6 mice (n = 3) received a single, 5 mg/kg subcutaneous dose of the indicated C5-targeted siRNA. Circulating C5 levels were measured by ELISA on days 7, 14, 21 and 28 post dose with each sample normalized to the pre-dose levels for the individual animal.